Cryptococcus neoformans activates RhoGTPases followed by PKC, FAK and ezrin to enhance traversal across the blood-brain barrier
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چکیده
Background: C. neoformans traverse across the BBB to penetrate into the brain. Results: C. neoformans activates RhoGTPases and subsequently PKC, FAK and ezrin in HBMEC. Conclusion: Activation of host signaling proteins promotes Cryptococcus crossing across the BBB. Significance: Elucidation of the host signaling events that contributes to cryptococcal BBB traversal is important for a better understanding of its pathogenesis.
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تاریخ انتشار 2012